研究内容

製剤物理化学研究室では、高分子多糖類を利用した製剤に関する研究に取り組んでいます。


1)高分子多糖類を利用した製剤基材への応用

2)高分子多糖類を利用した新規医薬品・サプリメントの開発


【原著論文】
1)Preparation and antioxidant activity of PEGylated chitosans with different particle sizes.
Anraku M., Hiraga A., Inohara D., Uekama K., Tomida H., Otagiri M., and Hirayama F.International Jouranl of Biological Macromolecules, 70, 64-69(2014)

2)Pleiotropic effects of chitosan on lifestylie-related diseases.
Anraku M., Maruyama T., Inohara D., Tomida H., Hirayama F., and Otagiri M.Chitin and Chitosan Research, 20, (2), 74-81(2014)

3)Antioxidant and renoprotective activity of chitosan in nephrectomized rats.
Anraku M., Tomida H., Michihara A., Tsuchiya D., Inohara D., Maezaki Y., Uekama K., Maruyama T., Otagiri M., and Hirayama F.Carbohydrate Polymers, 89, (1), 302-304(2012)

4)Flexibility of the coordination geometry around the cupric ions in Cu(U)-rat dipeptidyl peptidase V is important for the expression of enzyme activity.
Hirose J., Hata T., Kawaoka C., Ikeura T., Kitahara S., Tomida H., Iwamoto H., Ono Y., and Fukasawa M. K.Archives of Biochemistry and Biophysics, 525, (2012)71-81

5)Surveillance Study on Use of Over-the-Counter Drug and Health Foods by School Pharmacist for Grade-schooler, Junior High School Student, and High School Students.
Anraku M., Tomida H., Sato E., Tabuchi N., Yoshitomi H., Okamura N., Taguchi K., Kondo Y., Murakami N.Yakugaku Zasshi, 131(5),835-842, 2011.

6) Antioxidant properties of high molecular weight dietary chitosan in vitro and in vivo.
Anraku M., Fujii T., Kondo Y., Kojima E., Hata T., Tabuchi N., Tsuchiya D., Goromaru T., Tsutsumi H., Kadowaki D., Maruyama T., Otagiri M., Tomida H.Carbohydrate Poly., 83 : 501-505 (2011)

7) Useful Extend-release Chitosan Tablets with High Antioxidant Activity.
Yasufuku T., Anraku M., Kondo Y., Hata T., Hirose J., Kobayashi N., Tomida H. Pharmaceutics, 2 : 245-257 (2010).

8) The antioxidative and antilipidemic effects of different molecular weight chitosans in metabolic syndrome model rats.
Anraku M., Michihara A., Yasufuku T., Akasaki K., Tsuchiya D., Nishio H., Maruyama T., Otagiri M., Maezaki Y., Kondo Y., Tomida H. Biol Pharm Bull., 33 :1994-1998 (2010).

9) Surveillance Study in Collaboration with a University- Day-care Center for Elder People and Nursery School for Children on the Use of Over-the-Counter Drug and Health Foods in Fukuyama.
Anraku M., Inoue H., Sato E., Hata T., Tsuchiya D., Okamura N., Yoshitomi H., Kondo Y., Tanaka M., Tomida H. Yakugaku zasshi, 130 , :1093-1103 (2010).

10) Polysaccharides as potential antioxidative compounds for extended-release matrix tablets.
Tomida H., Yasufuku T., Fujii T., Kondo Y., Kai T., Anraku M. Carbohydr Res., 345 :82-86 (2010).

11) High levels of oxidative stress exist in the brain than serum or kidneys in stroke-prone spontaneously hypertensive rats at ten weeks of age.
Michihara A., Shimatani M., Anraku M., Tomida H., Akasaki K. Biol Pharm Bull., 33 : 518-521 (2010).

12) Antioxidant properties of some different molecular weight chitosans.
Tomida H., Fujii T., Furutani N., Michihara A., Yasufuku T., Akasaki K., Maruyama T., Otagiri M., Gebicki JM., Anraku M.Carbohydr Res., 344 :1690-1696 (2009).

13) Antioxidant effects of a dietary supplement: reduction of indices of oxidative stress in normal subjects by water-soluble chitosan.
Anraku M., Fujii T., Furutani N., Kadowaki D., Maruyama T., Otagiri M., Gebicki JM., Tomida H.Food Chem Toxicol., 47 :104-109 (2009).

14) Questionnaire Survey on Use of Health Foods and Over the Counter Drugs in Bingo Area Done in Collaboration with University Drug Store.
Anraku M., Sato E, Okamura N., Yoshitomi H., Furutani N., Yuhara M., Kajihara K., Hibino S., Tomida H. Jpn. J. Pharm. Health Care Sci., 35 : 487-494 (2009).

15) Antioxidant protection of human serum albumin by chitosan.
Anraku M., Kabashima M., Namura H., Maruyama T., Otagiri M., Gebicki JM., Furutani N., Tomida H. Int J Biol Macromol., 43 :159-164 (2008).


戻る